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When applying any changes to the Network Interface Card within Zettagrid, it always pays to restart the network services.
Open BSD
# sh /etc/netstart pnc0
FreeBSD
# /etc/rc.d/netif restart
CentOS / RHEL / Red Hat / Fedora
Example # /etc/init.d/network restart
# service network stop
# service network start
# service network restart
Debian / Ubuntu
Example # /etc/init.d/networking restart
# service networking stop
# service networking start
# service networking restart